Technology | June 27, 2006

Low Osmolality, Low Viscosity for Better Patient Outcomes

OXILAN (ioxilan) injection is a third-generation nonionic contrast medium offered by Guerbet in the U.S. It is a contrast agent used by radiologists, interventional radiologists and interventional cardiologists because of unique properties. It has low osmolality and viscosities among nonionic monomers in the U.S., which contributes to better patient outcomes such as patient comfort during intra-arterial injection and addresses physicians’ needs such as excellent image quality and easier injections.
OXILAN has a unique molecular structure which includes a hydrophobic region to promote molecular aggregation, thereby reducing the osmolality. Only those nonionic monomers that contain hydrophobic regions can achieve significantly lower solution osmolalities at diagnostically useful concentrations. This unique molecular design also features a terminal hydrophilic group, which results in reduced risk of side effects from binding with biological structures. The hydrophilic group also increases the solubility of the molecule.

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