News | February 02, 2010

Intracranial Radiosurgery for Metastases Led to Progressive Disease

February 2, 2010 - Researchers found that while using Gamma Knife radiosurgery was well-tolerated as initial therapy in the management of patients with sarcomatous intracranial metastases, many patients end up developing progressive brain disease.

Researchers wanted to determine the indication and outcomes for Gamma Knife stereotactic radiosurgery (GKSRS) in the care of patients with intracranial sarcomatous metastases. To do so , they looked at data from 21 patients who underwent radiosurgery for 60 sarcomatous intracranial metastases (54 parenchymal and 6 dural-based) were studied. Nine patients had radiosurgery for solitary tumors and 12 for multiple tumors.

The primary pathology was metastatic leiomyosarcoma (4 patients), osteosarcoma (3 patients), soft-tissue sarcoma (5 patients), chondrosarcoma (2 patients), alveolar soft part sarcoma (2 patients), and rhabdomyosarcoma, Ewing’s sarcoma, liposarcoma, neurofibrosarcoma, and synovial sarcoma (1 patient each). Twenty patients received multimodality management for their primary tumor, and 1 patient had no evidence of systemic disease. The mean tumor volume was 6.2 cm3 (range, 0.07–40.9 cm3), and a median margin dose of 16 Gy was administered. Three patients had progressive intracranial disease despite fractionated whole-brain radiotherapy before SRS.

They found that a local tumor control rate of 88 percent was achieved, including patients receiving boost, up-front, and salvage SRS. New remote brain metastases developed in 7 patients (33 percent). The median survival after diagnosis of intracranial metastasis was 16 months, and the 1-year survival rate was 61 percent.

Although the therapy was well-tolerated in the management of patients with sarcomatous intracranial metastases, they found that many patients, including those who also received fractionated whole-brain radiotherapy, developed progressive new brain disease.

Reference: Flannery, T; Kano, K; Niranjan, A. Gamma Knife Radiosurgery as a Therapeutic Strategy for Intracranial Sarcomatous Metastases. Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):513-519.

For more information: www.oncologystat.com

Related Content

American College of Radiology Releases New Patient-Oriented Appropriateness Criteria Summaries
News | Patient Engagement | January 19, 2018
January 19, 2018 — New Appropriateness Criteria (AC) Patient Summaries from the American College of Radiology (ACR) c
First Hospitals Achieve Inter-System Connectivity Across Accuray Radiation Therapy Platforms
News | Radiation Therapy | January 19, 2018
Accuray Inc. announced recently that the Heidelberg University Hospital in Heidelberg, Germany, and Oscar Lambret...
National Clinical Decision Support Company (NDSC) has an exclusive deal with the American College of Radiology (ACR) to provide medical imaging appropriate use criteria (AUC).

National Clinical Decision Support Company (NDSC) has an exclusive deal with the American College of Radiology (ACR) to provide medical imaging appropriate use criteria (AUC). 

Feature | Clinical Decision Support | January 18, 2018
January 18, 2018 — Change Healthcare announced the acquisition of National Decision Support Company (NDSC), a leader
RayStation Selected for New Carbon Ion Therapy Center in Japan
News | Treatment Planning | January 18, 2018
January 18, 2018 – RayStation has been chosen as the treatment planning system for a new carbon-ion therapy facility
Raysearch Receives First Order for the Raycare Oncology Information System
News | Oncology Information Management Systems (OIMS) | January 18, 2018
January 18, 2018 – Anderson Regional Cancer Center (ARCC) in Meridian, Mississippi, has placed the first order for...
Philips Introduces Technology Maximizer Program for Imaging Equipment Upgrades
Technology | Imaging | January 17, 2018
January 17, 2018 — Philips recently announced the launch of Technology Maximizer, a cross-modality program designed t
RSNA 2017 Celebrates Innovation in Radiology
News | Imaging | January 15, 2018
January 15, 2018 — The Radiological Society of North America’s...

Size comparison between 3-D printed prosthesis implant and a penny.

News | 3-D Printing | January 11, 2018
January 11, 2018 — Researchers using...
RSNA 2017 technical exhibits, expo floor, showing new radiology technology advances.
Feature | RSNA 2017 | January 11, 2018
January 11, 2018 — Here is a list of some of the key clinical study presentations, articles on trends and videos from
The artificial intelligence (AI) smart algorithm onboard the Infervision stroke product calculates the volume of bleed on the basis of multiple brain CT slices.

The AI smart algorithm onboard the Infervision stroke product calculates the volume of bleed on the basis of multiple brain CT slices. The size of the bleed volume indicates the urgency and type of treatment required.

Feature | Artificial Intelligence | January 10, 2018 | Greg Freiherr
Exhibitors at the 2017 Radiological Society of North American (RSNA) meeting rode the...
Overlay Init