News | July 31, 2007

IMRT Reduces Breast Cancer Treatment Side Effects

August 1, 2007 – According to a study released in the Aug. 1 edition of ASTRO’s official journal the International Journal of Radiation Oncology * Biology * Physics, women with early stage breast cancer who receive intensity modulated radiation therapy (IMRT) develop significantly fewer side effects than women who receive traditional radiation therapy.

IMRT is a specialized type of radiation therapy in which the radiation beam can be broken up into many beamlets, and the intensity of each beamlet can be adjusted individually. This allows radiation oncologists to more precisely shape the beam of radiation to better fit the individual contours of a women’s breast while avoiding dose to adjacent organs. With IMRT, the radiation dose to the breast is more uniformly distributed throughout the breast essentially minimizing “hot spots”.

Doctors at William Beaumont Hospital in Royal Oak, MI., evaluated 172 women with early stage breast cancer as part of this study. The patients were divided into two groups; 54 percent received IMRT, while 46 percent received conventional wedged-based radiation and served as the control group for the study.

Researchers specifically looked for changes in the breast directly associated with radiation therapy. They evaluated the instances of dermatitis (reddened or itchy skin), breast edema (swelling) and hyperpigmentation (changes in skin color) on the breast, and the correlation between these side effects and the type of radiation treatment given.

Women who received IMRT reported significantly fewer breast-related side effects overall compared to the women who received traditional radiation therapy.

“Earlier studies have demonstrated the benefits and importance of radiation therapy in the treatment of many women with breast cancer. It is exciting that we are now conducting studies with the goal of helping to make these treatments easier and more comfortable for women. This study, along with other recent data presented by our colleagues, demonstrates that improving dose homogeneity within the breast with IMRT results in significantly fewer side effects for women undergoing radiation therapy for early stage breast cancer,” said Asif Harsolia, M.D., lead author on the study and a radiation oncologist with The Permanente Medical Group in Santa Clara, CA. The study was conducted while Dr. Harsolia was a resident at William Beaumont Hospital in Royal Oak, MI.

For more information: www.astro.org

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