News | February 11, 2015

Image-Guided Radiotherapy Reduces Long-Term Treatment Side Effects

Results of a clinical trial conducted by the RTOG establish a new standard of care for the treatment of soft tissue sarcoma

February 11, 2015 — Patients with soft tissue sarcoma of an extremity treated with preoperative image-guided radiotherapy (IGRT) experience significantly fewer long-term treatment side effects compared with a historical control group treated with preoperative, non-image-guided radiation therapy (RT), according to results of the RTOG 0630 trial published online in the Journal of Clinical Oncology. At two years post treatment, 10 percent of patients (6/57) in the RTOG 0630 study experienced a moderate or worse side effect versus 37 percent of patients (27/73) in the historical control group. Specifically, treatment with IGRT was found to reduce the side effects of fibrosis (5.3 versus 31.5 percent), joint stiffness (3.5 versus 17.8 percent) and edema (5.3 versus 15.1 percent).

“The RTOG 0630 data demonstrate that IGRT with modern technology such as IMRT significantly improves outcomes for patients with soft tissue sarcoma and confirm that the radiotherapy parameters used in the trial should be considered appropriate for preoperative radiotherapy of extremity sarcoma,” says the trial principal investigator Dian Wang, M.D., Ph.D., a professor of radiation oncology at Rush University Medical Center in Chicago.

Wang points to two factors that likely led to the improved outcomes: more precisely targeting the tumor through daily imaging that guided patient positioning prior to RT treatment (especially important because immobilization devices used during radiotherapy of extremity sarcoma often are not rigid due to the tumor’s location) and the delivery of radiation to a much smaller target volume (with less normal tissue included) through the use of either intensity modulated radiotherapy or 3-D conformal radiotherapy. “This is one of the first multi-institutional studies—across all cancer types—to have a primary aim that investigated the benefits of image-guided modern technology and techniques for reducing radiotherapy related toxicities for our patients,” says Wang.

Soft tissue sarcomas often form in the body’s muscles, joints, fat, nerves, deep skin tissues and blood vessels. Though relatively rare (1 percent of all adult cancers), soft tissue sarcomas are quite deadly due to the presence of advanced disease, or metastasis, at initial diagnosis. Nearly 12,000 new cases of soft tissue sarcoma are expected to be diagnosed in 2015 with approximately 5,000 deaths from the disease projected.

For more information: www.nrgoncology.org

Related Content

ASTRO and ASCO Launch New Cancer Care Quality Registry
News | Radiation Therapy | January 22, 2018
January 22, 2018 — A registry that tracks the quality of medical care provided to patients receiving cancer treatment
First Hospitals Achieve Inter-System Connectivity Across Accuray Radiation Therapy Platforms
News | Radiation Therapy | January 19, 2018
Accuray Inc. announced recently that the Heidelberg University Hospital in Heidelberg, Germany, and Oscar Lambret...
RayStation Selected for New Carbon Ion Therapy Center in Japan
News | Treatment Planning | January 18, 2018
January 18, 2018 – RayStation has been chosen as the treatment planning system for a new carbon-ion therapy facility
Raysearch Receives First Order for the Raycare Oncology Information System
News | Oncology Information Management Systems (OIMS) | January 18, 2018
January 18, 2018 – Anderson Regional Cancer Center (ARCC) in Meridian, Mississippi, has placed the first order for...
Transpara Deep Learning Software Matches Experienced Radiologists in Mammogram Reading
News | Computer-Aided Detection Software | January 12, 2018
Deep learning and artificial intelligence improves the efficiency and accuracy of reading mammograms, according to...
Smartphone Addiction Creates Imbalance in Brain
News | Mobile Devices | January 11, 2018
Researchers have found an imbalance in the brain chemistry of young people addicted to smartphones and the internet,...
Fat Distribution in Women and Men Provides Clues to Heart Attack Risk
News | Women's Health | January 11, 2018
January 11, 2018 – It’s not the amount of fat in your body but where it is stored that may increase your risk for hea
Minimally Invasive Treatment Provides Relief from Back Pain

Lumbar spine MRI showing disc herniation and nerve root at baseline and one month after treatment

News | Interventional Radiology | January 11, 2018
The majority of patients were pain free after receiving a new image-guided pulsed radiofrequency treatment for low back...
Emergency Radiologists See Inner Toll of Opioid Use Disorders

Rates of Imaging Positivity for IV-SUDs Complications. Image courtesy of Efren J. Flores, M.D.

News | Clinical Study | January 11, 2018
January 11, 2018 – Emergency radiologists are seeing a high prevalence of patients with complications related to opio
CT Shows Enlarged Aortas in Former Pro Football Players

3-D rendering from a cardiac CT dataset demonstrating mild dilation of the ascending aorta.

News | Computed Tomography (CT) | January 11, 2018
Former National Football League (NFL) players are more likely to have enlarged aortas, a condition that may put them at...
Overlay Init