Carestream Molecular Imaging, a division of Carestream Health, Inc., announced at the Joint Molecular Imaging Conference the introduction of KODAK X-SIGHT, new large stokes shift dyes for fluorescent in vivo imaging applications, which are reactive dyes designed to enable researchers and scientists to maximize the fluorescent signal while minimizing auto-fluorescence issues during in vivo imaging.
“Stokes shift” refers to the separation of absorption and emission maxima. Having a significantly larger Stokes shift—greater than 80 nanometers in the case of KODAK X-SIGHT Dyes—helps researchers eliminate much of the background that typically obstructs the fluorescent signal while allowing researchers to excite and emit the dyes at their maxima, thus resulting in far greater signal to noise. Most commercially available dyes typically have a Stokes shift between 20-30 nanometers.
In an organism, the KODAK X-SIGHT Dyes can illuminate a region of interest when excited by the appropriate wavelength of fluorescent light, thus allowing the researcher to visualize their target. While the KODAK X-SIGHT Imaging Agents have been optimized for KODAK Image Station and In-Vivo Systems, they are also compatible with other commercially available digital imaging systems.
“Our new KODAK X-SIGHT Large Stokes Shift Dyes, characterized by near infrared emission and a large Stokes shift, enable researchers to achieve a higher sensitivity of fluorescent detection deeper into tissue,” said Shahram Hejazi, PhD, President of Carestream Molecular Imaging. “With superior performance when compared to other commercially available products, these new dyes validate our outstanding dye chemistry expertise and leadership in fluorescent imaging.”
KODAK X-SIGHT Dyes will be available this fall for preclinical use.