April 23, 2009 - 3T MRI can detect a significant number of lesions not found on mammography and sonography, according to a study performed at the University of Toledo Medical Center, Toledo, OH. The study included 434 women who underwent mammography, sonography and 3T MRI for the detection of malignant breast lesions-all women were at high risk. Results showed that 3T MRI detected 66/66 malignant lesions; mammography detected 54/66 malignant lesions; and sonography detected 57/66 malignant lesions. "3T MRI depicted a significantly higher number of malignant tumors of the breast than mammography and sonography," said Haitham Elsamaloty, M.D., lead author of the study. "Our study detected 'early' breast cancer (lesions as small as 4 mm) in size and also identified malignant lesions that were only detected by MRI and confirmed by MRI guided biopsy. These crucial findings led to a significant change in patient management in 18.2 percent of the cases in our study. "Our study suggests an important role for 3T MRI in such high risk groups for an early diagnosis of breast cancer and better accuracy in evaluating the extent of disease-a crucial factor in appropriate therapy planning," said Dr. Elsamaloty. "High field strength (3T) MRI systems are becoming increasingly available in the clinical setting and more of them are being used for the evaluation of breast malignancy. 3T MRI is an important addition to mammography and sonography," he said. Source: This study appears in the April issue of the American Journal of Roentgenology. For more information: www.ajronline.org
3T MRI Detects "Early" Breast Cancer Not Seen On Mammography, Ultrasound
Images in a 55-year-old screening participant. (a, b) Normal digital full-field mediolateral oblique (a) and craniocaudal (b) mammograms (BI-RADS category 1) show a heterogeneously dense breast (ACR category C). (c) Screening ultrasound image shows normal findings (BI-RADS category 1). (d) MR-guided biopsy enabled us to confirm the presence of an invasive high-grade triple-negative cancer (no special type [NST], pT1b, N0, M0). (d) Breast MR image shows a suspicious enhancing mass (arrow) in the left breast (BI-RADS category 5). Image courtesy of the Radiological Society of North America.