Feature | Contrast Media | July 18, 2019 | By Greg Freiherr

AHRA Talk To Focus on Risk Management of MR Contrast Media

Two brain metastases from primary lung cancer are contrast enhanced in the brain of a 61-year-old male. Speakers at AHRA 2019 will state that ProHance and other macrocyclic MR agents present a very low risk to patients. Images courtesy of Bracco

Two brain metastases from primary lung cancer are contrast enhanced in the brain of a 61-year-old male. Speakers at AHRA 2019 will state that ProHance and other macrocyclic MR agents present a very low risk to patients. Images courtesy of Bracco


Macrocyclic contrast agents have the best safety profile of all the magnetic resonance (MR) contrast media that are now commercially available, according to John Karis, M.D., director of neuroradiology at the Barrow Neurological Institute.

Their safety profile is so compelling that the Phoenix -based institute switched to using macrocyclics for the vast majority of its MR contrast-enhanced scans. The institute settled recently on a single macrocyclic agent, ProHance, Karis told Imaging Technology News.

“We switched initially to a different macrocyclic but then switched to ProHance based on hospital contract issues,” he said. Although ProHance currently is the “default” MR agent, “there are a few research situations where we might use some other agents,” said Karis, who noted that the three macrocylic agents currently on the market “all have extremely good safety profiles.”

At The Association for Medical Imaging Management (AHRA) 2019 meeting, on July 21 at 5:30 pm, he and Nicolas Argy, M.D., J.D., a Bracco consultant, are scheduled to describe ways to manage risks from MR contrast media. The goal, Karis said, is to give audience members “all the information they need to make intelligently formed decisions for their site about what would be the best agent to use and, if (they decide to make) a change, what is the best and most effective way to do it.”

The name of the AHRA symposium, “A New Perspective on Risk Management in MR Contrast,” is based on the short experience that physicians have with these agents, according to Karis. The first such gadolinium-based agent was commercialized in 1987, he said. Since then, millions of doses have been administered with “very, very few adverse outcomes.”

 

Patient Safety First

During the symposium, safety profiles of different MR contrast media will be presented, as well as the pharmacology underlying them. Also addressed, according to Karis, will be complications of MR contrast including NSF (nephrogenic systemic fibrosis); immediate adverse reactions such as allergies, vomiting and feelings of heat or cold; and issues surrounding gadolinium retention.

It was out of concern for patient safety that the Barrow Neurological Institute switched to macrocyclics, he said. Although these agents are more expensive than linear ones, their small cost differential can be offset by improved efficiency, according to Karis.

The switch at the institute did not happen suddenly. Because different workflows in the MR suite accompany different types of MR contrast agents, the Barrow Neurological Institute gradually transitioned to macrocyclics “to make sure that all our technologists and physicians were comfortable with the switch and bought into it,” he said.

Key considerations in transitioning to macrocyclics will be discussed at the symposium, in the context of ways to reduce risk from the use of MR contrast. Karis plans to caution attendees against the administration of any IV drugs unless their use is necessary.

 

Greg Freiherr is a contributing editor to Imaging Technology News. Over the past three decades, Freiherr has served as business and technology editor for publications in medical imaging, as well as consulted for vendors, professional organizations, academia, and financial institutions.

 

Editor’s note: This article is the third piece in a content series by Greg Freiherr covering The Association for Medical Imaging Management (AHRA) annual meeting in Denver. The first article, How Standardizing Protocols Can Save Time and Money, can be found here. The second article, How Artificial Intelligence Might Impact Radiology, can be found here.

 

Related content:

How Standardizing Protocols Can Save Time and Money

How Artificial Intelligence Might Impact Radiology

Gadolinium-Based Imaging Agent Boasts Safety, Reliability 

FDA Calls for Patient Education, More Clinical Studies for Gadolinium-based Contrast Agents (GBCAs) 

Gadolinium-Based MRI Contrast Agents Linked to Potentially Fatal Disease 


Related Content

News | Artificial Intelligence

November 29, 2022 — Quantivly is highlighting new advances in its artificial intelligence (AI)-driven software for ...

Time November 29, 2022
arrow
News | Magnetic Resonance Imaging (MRI)

November 29, 2022 — Two studies comparing injections commonly used to relieve the pain of knee osteoarthritis found that ...

Time November 29, 2022
arrow
News | Pediatric Imaging

November 28, 2022 — Using MRI data from the largest long-term study of brain development and child health in the United ...

Time November 28, 2022
arrow
News | RSNA

November 27, 2022— Royal Philips, a global leader in health technology, today announces its portfolio of smart ...

Time November 27, 2022
arrow
News | Computed Tomography (CT)

November 26, 2022 — As international leaders in the field of Imaging gather for the 2022 Radiological Society of North ...

Time November 26, 2022
arrow
News | Contrast Media

November 26, 2022 — Guerbet LLC, the US affiliate of Guerbet, a global leader in medical imaging offering a ...

Time November 26, 2022
arrow
News | Enterprise Imaging

November 26, 2022 — FUJIFILM Healthcare Americas Corporation, a leading provider of enterprise imaging and informatics ...

Time November 26, 2022
arrow
News | Pediatric Imaging

November 23, 2022 — Researchers analyzing the data from MRI exams on nearly 8,000 children have identified biomarkers of ...

Time November 23, 2022
arrow
News | Magnetic Resonance Imaging (MRI)

November 23, 2022 — For the first time, a new study has identified enlarged perivascular spaces in the brains of ...

Time November 23, 2022
arrow
News | Pediatric Imaging

November 22, 2022 — A new MRI study revealed that consumption of alcohol even in low to moderate amounts during ...

Time November 22, 2022
arrow
Subscribe Now