Feature | October 03, 2013

Accuray Involved in More Than 100 ASTRO Presentations

Data Supports Growing Use of CyberKnife SBRT for Prostate Cancer

radiation therapy radiontherapy cyberknife tomotherapy systems

October 3, 2013 — Accuray Incorporated announced that studies presented at the American Society for Radiation Oncology (ASTRO) 55th Annual Meeting continue to reinforce evidence of clinical and quality of life benefits for the CyberKnife and TomoTherapy Systems.

 

Cyberknife Clinical and Technical Study

The 43 CyberKnife presentations focused on a range of indications including lung, brain, kidney, and prostate stereotactic body radiation therapy (SBRT), which was the topic of 14 presentations. The emphasis on CyberKnife prostate SBRT was timely, given ASTRO’s recently announced update to its model policy on SBRT which states that SBRT is an appropriate alternative for select patients with low to intermediate risk disease.

Two[i] prospective Phase II studies found that the quality of life for patients undergoing CyberKnife SBRT for prostate cancer “compare favorably to published results from radical prostatectomy and intensity-modulated radiation therapy.”

One[ii] study of lung SBRT with the CyberKnife System reported lower chest wall maximum dose when lesions were tracked with the Synchrony Respiratory Tracking System compared to static or linac-based treatment plans, and another study[iii] showed very low incidence of chest wall pain, a common side effect of lung SBRT for lesions near the chest wall.

Three[iv] treatment planning simulation studies incorporating the multileaf collimator of the new CyberKnife M6 System found consistent reductions in treatment time for both radiosurgery and intensity-modulated radiation therapy (IMRT) plans, with equivalent or improved plan quality relative to the prior circular collimator plans or IMRT plans generated for other radiotherapy systems.

 

TomoTherapy Clinical and Technical Study

Of the 61 TomoTherapy presentations, several focused on treatment of breast, head and neck, prostate and lung cancers. The studies showed the breadth and depth of the TomoTherapy system as an efficient treatment option for a wide range of patients and disease types clinically proven to provide strong disease control and low incidence of toxicity.

One[v] notable study showed TomoDirect can be used to deliver hypofractionated whole breast radiotherapy with a simultaneous boost to the resection cavity. Authors concluded TomoDirect was, “…an efficient means to deliver accelerated hypofractionated [treatment]...with an optimal dose distribution, negligible toxicity and encouraging clinical results.”

Another study[vi] presented long-term outcomes of post-operative helical TomoTherapy treatment of malignant pleural mesothelioma. Overall survival was “among the best observed in recent studies, supporting the idea that this approach represents an alternative option to extrapleural pneumonectomy.”

In a related study[vii], authors confirmed in patients with malignant pleural mesothelioma that either adjuvant conventionally fractionated or definitive hypofractionated TomoTherapy treatment results in a high prescription dose to the treatment volume while sparing organs at risk.

A third study[viii] showed that use of VoLO planning, the GPU-based dose calculation system, results in “a considerable saving of time during the calculation process” without significant changes in plan quality.

For more information: www.accuray.com

 

References:  

[i] Chen et al., Quality of Life (QOL) Outcomes Through 3 Years After Stereotactic Body Radiation Therapy (SBRT) for Early Prostate Cancer: Results From a Multi-institutional Phase 2 Trial. 55th Annual American Society for Radiation Oncology (ASTRO) Meeting, Atlanta, Georgia, September 22 – 25, 2013. Meier et al., Patient-Reported Quality of Life Outcomes in Intermediate-Risk Prostate Cancer Patients Treated With Stereotactic Body Radiation Therapy. 55th Annual American Society for Radiation Oncology (ASTRO) Meeting, Atlanta, Georgia, September 22 – 25, 2013.

[ii] Goldin et al., Stereotactic Body Radiation Therapy for Early Stage Lung Cancer: Quantifying the Effect of Tracking With Respiratory Motion on Chest Wall Dosimetry. 55th Annual American Society for Radiation Oncology (ASTRO) Meeting, Atlanta, Georgia, September 22 – 25, 2013.

[iii] Podder et al., Chest Wall and Rib Irradiation of Lung Cancer Patients Treated With Robotic Radiosurgery SBRT. 55th Annual American Society for Radiation Oncology (ASTRO) Meeting, Atlanta, Georgia, September 22 – 25, 2013.

[iv] Kole et al. Improved Normal Tissue Sparing and Reduced Treatment Time Using Multileaf Collimator Robotic Radiosurgery Stereotactic Body Radiation Therapy (SBRT) Compared to Iris Collimator SBRT in Treatment of Localized Prostate Cancer. 55th Annual American Society for Radiation Oncology (ASTRO) Meeting, Atlanta, Georgia, September 22 – 25, 2013. Wang et al. Beam Selection for MLC-Based Robotic Radiation Therapy. 55th Annual American Society for Radiation Oncology (ASTRO) Meeting, Atlanta, Georgia, September 22 – 25, 2013. McGuinness et al., Standard Fractionation IMRT With a MLC-Equipped Robotic Radiosurgery System.  55th Annual American Society for Radiation Oncology (ASTRO) Meeting, Atlanta, Georgia, September 22 – 25, 2013.

[v] Franco et al., Hypofractionated Adjuvant Breast Radiation and Simultaneous Integrated Boost Delivered With Static Angle Tomotherapy: A Prospective Phase 2 Trial. 55th Annual American Society for Radiation Oncology (ASTRO) Meeting, Atlanta, Georgia, September 22 – 25, 2013.

[vi] Trovo et al., Radical Pleurectomy/Decortication Followed by High Dose of Radiation Therapy Delivered With Tomotherapy for Malignant Pleural Mesothelioma: Final Results With Long-term Follow-up. 55th Annual American Society for Radiation Oncology (ASTRO) Meeting, Atlanta, Georgia, September 22 – 25, 2013.

[vii] Parisi et al. Tomotherapy in the Treatment of Malignant Pleural Mesothelioma.  55th Annual American Society for Radiation Oncology (ASTRO) Meeting, Atlanta, Georgia, September 22 – 25, 2013.

[viii] Mohr et al., Accelerated GPU-Based Tomotherapy Planning.  55th Annual American Society for Radiation Oncology (ASTRO) Meeting, Atlanta, Georgia, September 22 – 25, 2013.

 

Related Content

Technology becomes a state-of-the-art tool when it gets exposed to a structure that constantly tests it and allows it to evolve.

Technology becomes a state-of-the-art tool when it gets exposed to a structure that constantly tests it and allows it to evolve. Getty Images

Feature | Oncology Information Management Systems (OIMS) | May 27, 2020 | By Reshu Gupta
In the history of medicine, researchers have found cures for many diseases, but cancer has been elusive.
Miami Cancer Institute’s Proton Therapy Center is the first in South Florida and the region’s top destination for this leading-edge treatment. Proton therapy is an advanced form of radiation therapy that uses pencil beam scanning (PBS) technology.

Miami Cancer Institute’s Proton Therapy Center is the first in South Florida and the region’s top destination for this leading-edge treatment. Proton therapy is an advanced form of radiation therapy that uses pencil beam scanning (PBS) technology.

Feature | Proton Therapy | May 27, 2020 | By Minesh Mehta, M.D.
Radiation therapy has advanced significantly in the last few decades as a result of a continued technological revolut
The global radiation therapy market is expected to reach $10.11 billion in 2024, witnessing growth at a CAGR of 3.38%, over the period 2020-2024.
News | Proton Therapy | May 20, 2020
May 20, 2020 — ResearchAndMarkets.com has released its latest report, the ...
An innovative radiation treatment that could one day be a valuable addition to conventional radiation therapy for inoperable brain and spinal tumors is a step closer, thanks to new research led by University of Saskatchewan (USask) researchers at the Canadian Light Source (CLS).

USask PhD bio-medical engineering student Farley Chicilo at the Canadian Light Source synchrotron at University of Saskatchewan. Photo courtesy of Canadian Light Source, University of Saskatchewan

News | Radiation Therapy | May 14, 2020
May 14, 2020 — An innovative radiation treatment t
Medical University of South Carolina researchers have developed and validated prediction tools, known as nomograms, that could be used to help prevent delays in the initiation of radiotherapy after surgery for head and neck cancer

 

Evan Graboyes, M.D., and his team believe their nomogram tools will improve survival rates for head and neck cancer patients. Photo courtesy of MUSC Hollings Cancer Center

 

News | Radiation Oncology | May 14, 2020
May 14, 2020 — More than 65,000 Americans are diagnosed annually with head and neck cancer, which most often occurs i
Due to ongoing health concerns related to the spread of the Coronavirus (COVID-19) as well as global travel restrictions, the American Association of Physicists in Medicine (AAPM) has decided to evolve the Joint AAPM/COMP (Canadian Organization of Medical Physicists) Meeting content into a virtual (completely online) meeting in place of the in-person meeting originally scheduled for July 12-16, 2020, in Vancouver, BC.
News | AAPM | May 11, 2020
May 11, 2020 — Due to ongoing health concerns related to the spread of the Coronavirus (...
Figure 1: CT image of lesions in different planes

Figure 1: CT image of lesions in different planes.

Sponsored Content | Case Study | Radiation Oncology | April 30, 2020 | By Christopher Bowen, M.S., DABR
360 Photos | 360 View Photos | April 30, 2020
The company .decimal at ASTRO showed a 3-D prin
Two-dimensional (2D) Ruddlesden-Popper phase layered perovskites (BA)2(MA)2Pb3I10 with three layers of inorganic octahedral slab and bulky organics as spacers

Two-dimensional (2D) Ruddlesden-Popper phase layered perovskites (BA)2(MA)2Pb3I10 with three layers of inorganic octahedral slab and bulky organics as spacers. Image courtesy of Dave Tsai/Los Alamos

News | X-Ray | April 24, 2020
April 24, 2020 — Getting an X-ray at the dentist or