News | November 29, 2007

Stereoscopic Digital Mammo Detects More Cancers with Fewer False Positives

November 29, 2007 - Results of a clinical trial being conducted at Emory University Breast Clinic in Atlanta and presented at RSNA suggest that stereoscopic digital mammography, a new diagnostic technique capable of producing three-dimensional, in-depth views of breast tissue, could significantly reduce the number of women who are recalled for additional tests following routine screening mammography.

When stereoscopic digital mammography images are viewed on a stereo display workstation, the two digital X-ray breast images that are acquired from two different points of view and separated by approximately eight degrees, allow the radiologist to see the internal structure of the breast in three dimensions. For the ongoing clinical trial, researchers use a full-field digital mammography unit modified to take stereo pairs of images. With the aid of the workstation, the stereo image pair is fused to view the breast in depth.

"Stereo viewing is the only way to see the structure within the breast volume in true depth," said Dr. Getty, who has been working on the development of the technology over the past 12 years.

As of July 2007, the trial consisted of 1,093 patients at elevated risk for developing breast cancer. Each patient received a full-field, standard digital mammography screening examination and a full-field, stereoscopic digital exam, which were then read independently by different radiologists.

A total of 259 suspicious findings were detected by the combined mammography procedures and were referred for additional diagnostic testing, including biopsy when indicated. Of those, 109 were determined to be true lesions. Standard mammography missed 40 of the 109 lesions while the stereoscopic exam failed to detect 24.

"Our early results suggest that stereo digital mammography could contribute to the earlier detection of cancer," Dr. Getty said. "A small percentage of the additional lesions missed by standard mammography but detected by stereoscopic mammography will turn out to be cancerous."

Of the 259 findings, 150 were false positives; meaning further testing revealed that no abnormality was present. Standard mammography yielded 103 false positives; stereo mammography yielded 53.

"In our study, stereo digital mammography reduced false positives by 49 percent," said Dr. Getty. "This could have a significant impact by cutting in half the number of women who are needlessly recalled for additional diagnostic work-ups, resulting in a large savings in cost and patient anxiety."
According to Dr. Getty, making only minor changes to digital mammography equipment and software would allow facilities to offer wide-scale stereoscopic digital mammography.

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