News | Prostate Cancer | June 17, 2016

Illinois Hospital Offering C-11 Choline PET Imaging for Prostate Cancer

Studies show imaging with radiotracer increases detection rates by 32 percent

June 17, 2016 — Decatur Memorial Hospital, Decatur, Ill., is now offering C-11 choline positron emission tomography (PET)/computed tomography (CT) and PET/magnetic resonance imaging (MRI) to patients who have biochemical relapse of prostate cancer. This comes after completing a two-year clinical trial to detect prostate cancer in earlier stages.

C-11 choline PET/CT uses a U.S. Food and Drug Administration (FDA)-approved tracer which, after injection, highlights the precise location of prostate cancer with much greater precision and sensitivity than traditional scans.

Decatur Memorial Hospital is one of a very few hospitals in the United States able to provide this imaging procedure.

“The adoption of a C-11 choline PET/CT imaging program puts the DMH Cancer Care Institute at the forefront of advancements in detection and treatment of prostate cancer,” said Decatur Memorial Hospital President & CEO Timothy D. Stone Jr. “This technology gives us an extremely unique tool to potentially save more lives through earlier detection and more effective treatment.”

Prostate cancer affects one in six men in America. In 2016, approximately 180,000 men will be diagnosed with prostate cancer, and approximately 26,000 men will die from the disease annually. According to published reports, most men who die of prostate cancer do so after either primary local or systemic therapy has failed.

Suspected prostate recurrence is based upon elevated blood prostate specific antigen (PSA) levels following initial therapy. Conventional imaging tools such as CT scan, bone scan or MRI might show the precise location of prostate cancer only once PSA has reached a value of 20.0 ng/mL – 30.0 ng/mL. The optimum PSA value for lesion detection was determined to be between 1.7 and 2.0 ng/mL to obtain a maximal clinical benefit for detection of prostate cancer in men who have a biochemical relapse after primary treatment. This earlier and more precise detection can allow treatment to begin sooner and to be more accurately targeted.

Following the injection of C-11 choline, prostate cancer cells absorb the choline and the scanner picks up the exact locations of tracer concentrations. Lesions appear as brightly illuminated spots or areas on the scan. C-11 choline has a rapid rate of decay, losing half of its radioactivity every 20 minutes, which means the tiny amount of original radioactivity is gone quickly from the patient’s body.

In the largest published study in the U.S. on C-11 choline imaging, there was a 32 percent increased detection rate of prostate cancer lesions which were not identified on conventional CT scan and bone scan.

DMH Cancer Care Institute recently concluded a two-year clinical research trial for recurrent prostate cancer. The trial was designed to measure the performance characteristics of C11-choline PET/CT and PET/MRI in the detection of metastatic prostate cancer in patients with a relapse of cancer after primary treatment.

Nearly 110 men between the ages of 51 and 86 underwent a C11-choline PET/CT and MRI scan at Decatur Memorial Hospital as part of this trial and were evaluated for evidence of metastatic prostate cancer. Results of the study are still in progress but assessment to date is consistent with reports from Europe and the Mayo Clinic.

“C-11 choline is changing the way we detect and treat prostate cancer. It allows us to pinpoint the exact location of cancer in the body,” said urologic oncologist Thomas H. Tarter, M.D., Ph.D. “This level of accuracy at the very early stages of cancer allows for faster, more effective treatment that can increase survival rates. It’s applied technology that touches patients.”

C-11 choline is produced on-site at Decatur Memorial Hospital with a cyclotron, developed by GE. Decatur Memorial Hospital was the first non-commercial, non-academic GE PETtrace site to develop and implement on-site use of a cyclotron to produce nuclear isotopes in the performance of various diagnostic imaging tests and day-to-day clinical operation of patient care.

For more information: www.dmhcares.com

Related Content

United Imaging Announces First U.S. Clinical Install of uMI 550 Digital PET/CT System
News | PET-CT | June 19, 2019
United Imaging announced the first U.S. clinical installation of the uMI 550 Digital positron emission tomography/...
Black Men Less Likely to Adopt Active Surveillance for Low-Risk Prostate Cancer
News | Prostate Cancer | June 17, 2019
A new study reveals black men are less likely than white men to adopt an active surveillance strategy for their...
International Working Group Releases New Multiple Myeloma Imaging Guidelines

X-ray images such as the one on the left fail to indicate many cases of advanced bone destruction caused by multiple myeloma, says the author of new guidelines on imaging for patients with myeloma and related disorders. Image courtesy of Roswell Park Comprehensive Cancer Center.

News | Computed Tomography (CT) | June 17, 2019
An International Myeloma Working Group (IMWG) has developed the first set of new recommendations in 10 years for...
A high-fidelity 3-D tractography of the left ventricle heart muscle fibers of a mouse

Figure 1. A high-fidelity 3-D tractography of the left ventricle heart muscle fibers of a mouse from Amsterdam Ph.D. researcher Gustav Strijkers.

News | Magnetic Resonance Imaging (MRI) | June 07, 2019
The Amsterdam University Medical Center has won MR Solutions’ Image of the Year 2019 award for the best molecular...
BGN Technologies Introduces Novel Medical Imaging Radioisotope Production Method
News | Radiopharmaceuticals and Tracers | June 05, 2019
BGN Technologies, the technology transfer company of Ben-Gurion University (BGU), introduced a novel method for...
RefleXion Opens New Manufacturing Facility for Biology-guided Radiotherapy Platform
News | Radiation Therapy | May 31, 2019
RefleXion Medical recently announced the opening of its new manufacturing facility at its headquarters in Hayward,...
Improved Imaging for Prostate Cancer Could Lead to More Effective Treatment

The picture shows that time series signal is extracted from a series of ultrasound frames for classification. Each patch across a number of frames inside the prostate is classified into either cancerous or normal tissue. The image at the lower right corner shows the overall result for those frames. Image courtesy of Pingkun Yan and researchers from NIH, University of British Columbia and Queens University.

News | Ultrasound Imaging | May 28, 2019
Engineers at Rensselaer Polytechnic Institute are working to improve imaging methods in order to make medicine more...
Study Explores Magnetic Nanoparticles as Bimodal Imaging Agent for PET/MRI

Image courtesy of MR Solutions.

News | PET-MRI | May 23, 2019
Researchers from Bourgogne University in Dijon, France, showed that use of superparamagnetic iron oxide nanoparticles (...
New Phase 2B Trial Exploring Target-Specific Myocardial Ischemia Imaging Agent
News | Radiopharmaceuticals and Tracers | May 17, 2019
Biopharmaceutical company CellPoint plans to begin patient recruitment for its Phase 2b cardiovascular imaging study in...
Blue Earth Diagnostics Expands Access to Axumin in Europe
News | Radiopharmaceuticals and Tracers | May 13, 2019
Blue Earth Diagnostics announced expanded access to the Axumin (fluciclovine (18F)) imaging agent in Europe. The first...