News | Radiation Therapy | February 15, 2019

New Targeted Therapy for Recurrent Brain Tumors Implanted for First Time

GT MedTech’s GammaTile Therapy shown to slow brain tumor progression, designed to improve patient and caregiver quality of life

New Targeted Therapy for Recurrent Brain Tumors Implanted for First Time

February 15, 2019 – University of Minnesota Health (M Health) is the first in the United States to begin offering GammaTile Therapy, a new approach to treating recurrent brain tumors. GammaTile Therapy is a U.S. Food and Drug Administration (FDA)-cleared, surgically targeted radiation therapy (STaRT) manufactured by GT Medical Technologies that is designed to delay tumor regrowth for patients with brain tumors.

The first patient was treated by University of Minnesota physician Clark C. Chen, M.D., Ph.D., head of the Department of Neurosurgery at the University of Minnesota Medical School.

“At University of Minnesota Health, our mission is to advance new, safe and effective therapeutic options for the many brain tumor patients who did not respond to the standard-of-care therapies,” Chen said. “Moreover, the University of Minnesota Medical School’s Department of Neurosurgery has a long-standing history of contribution in radio-biologics. To be the first institution in the U.S. to offer the GammaTile Therapy is particularly satisfying in this context.”

Aggressive brain tumors tend to be resistant to current treatments and nearly always recur. Outcomes for patients with brain tumors have improved very little over the past 30 years. GammaTile is FDA-cleared for patients with recurrent brain tumors. It consists of a bioresorbable, conformable 3-D-collagen tile embedded with a Cesium radiation source. GammaTile is placed at the time of surgery so that it immediately begins to target residual tumor cells with radiation while limiting the impact on healthy brain tissue.

“I am optimistic that GammaTile will impact the clinical outcome for our brain tumor patients, particularly when combined with appropriate medical therapy,” explained Chen.

GammaTile Therapy offers some advantages over other treatments for patients undergoing surgery for recurrent brain tumors. A course of external beam radiation therapy (EBRT), for example, requires daily treatments for up to six weeks; in contrast, patients treated with GammaTile Therapy require no additional trips to the hospital or clinic. Additionally, many patients may not be candidates for EBRT at the time of tumor recurrence because the risk of additional EBRT outweighs the potential benefits. Finally, those patients who may be candidates for EBRT typically have to wait four weeks or more for surgical wound healing before beginning treatment, allowing residual, microscopic tumors to grow during this waiting period.

Chen has conducted research that supports the efficacy of radiation treatment immediately after resection. Published in the Journal of Neuro-Oncology, Chen’s study showed that patients with glioblastoma, the most common form of primary brain cancer in adults who received immediate postoperative radiation exhibited improved survival relative to those who did not.

“I am pleased to be able to offer a more targeted radiation therapy to my patients,” said Kathryn E. Dusenbery, M.D., head of the Department of Radiation Oncology at the University of Minnesota Medical School. “With GammaTile, we apply radiation therapy exactly where it is needed, without harming surrounding tissue, and patients do not need to come back for ongoing radiation treatments. In addition, this new targeted approach may help reduce the burden of ongoing radiation treatment and help my patients and their caregivers experience a better quality of life.”

Additional data supporting the efficacy and safety profile of the therapy for patients with recurrent, previously treated meningiomas were published last month in the Journal of Neurosurgery (JNS), the official journal of the American Association of Neurological Surgeons (AANS). Clinical data from other types of tumors will be presented at the AANS Annual Scientific Meeting, April 13-17 in San Diego.

For more information: www.gtmedtech.com

Related Content

Accuray Launches Synchrony Motion Tracking and Correction Technology for Radixact System
Technology | Image Guided Radiation Therapy (IGRT) | April 24, 2019
Accuray announced the launch of its Synchrony motion tracking and correction technology to be used with the Radixact...
New Study Redefines Therapeutic Dose Guidelines for Non-Small Cell Lung Cancer
News | Lung Cancer | April 23, 2019
Non-small cell lung cancer is a common cancer for both men and women. Many people who are diagnosed with this type of...
Comparison of state Medicaid fees for radiation oncology services for breast cancer and nonradiation oncology services per the Kaiser Family Foundation Index

Fig. 1: Comparison of state Medicaid fees for radiation oncology services for breast cancer and nonradiation oncology services per the Kaiser Family Foundation Index. (Agarwal et al, Red Journal, 2019) Credit: Elsevier

News | Radiation Therapy | April 22, 2019
April 22, 2019 — A new study finds wide state
Stereotactic Radiosurgery Effective for Pediatric Arteriovenous Malformation Patients
News | Radiation Therapy | April 19, 2019
Ching-Jen Chen, M.D., of the neurosurgery department at the University of Virginia (UVA) Health System, was the winner...
Surgically Guided Brachytherapy Improves Outcomes for Intracranial Neoplasms
News | Brachytherapy Systems | April 18, 2019
Peter Nakaji, M.D., FAANS, general practice neurosurgeon at Barrow Neurological Institute, presented new research on...
ASTRO Applauds Introduction of PIMA Patient Protection Bill
News | Radiology Business | April 15, 2019
The American Society for Radiation Oncology (ASTRO) hailed the introduction of federal legislation that would...
Varian Discloses First Preclinical Results of Flash Therapy in Cancer Treatment
News | Proton Therapy | April 09, 2019
Varian, in partnership with the University of Maryland School of Medicine’s Department of Radiation Oncology and the...
Varian Halcyon Commissioned at MedStar Southern Maryland Hospital Center With IBA's myQA Halo
News | Quality Assurance (QA) | April 04, 2019
IBA (Ion Beam Applications S.A.) announced the successful commissioning of the Varian Halcyon at the Radiation Oncology...
Four of the top pieces of content in March included news on proton therapy, including a 360 image and videos from ITN's recent visit to the Northwestern Medicine Proton Center in the Chicago suburbs. This image shows the main proton treatment room gantry at the proton center in Warrenville, Ill. Interview with Mark Pankuch, Ph.D.

Four of the top pieces of content in March included news on proton therapy, including a 360 image and videos from ITN's recent visit to the Northwestern Medicine Proton Center in the Chicago suburbs. This image shows the main proton treatment room gantry at the proton center in Warrenville, Ill.
 

Feature | April 02, 2019 | Dave Fornell, Editor and A.J. Connell
April 2, 2019 — Here is the list of the most popular content on the Imaging Technology News (ITN) magazine w