News | Interventional Radiology | July 31, 2019

International Multidisciplinary Group Publishes Recommendations for Personalized HCC Treatment With Y90 TheraSphere

Hepatocellular carcinoma guidelines supported by comparative Dosisphere data, a phase II multicentric randomized dosimetry trial

International Multidisciplinary Group Publishes Recommendations for Personalized HCC Treatment With Y90 TheraSphere

July 31, 2019 — New consensus recommendations for personalized treatment for hepatocellular carcinoma (HCC) with BTG’s TheraSphere have been published by an international multidisciplinary working group1. In addition, data from the Dosisphere phase II dosimetry trial supports MAA single photon emission computed tomography (SPECT)/CT-based prospective personalized dosimetry2.

Prof. Etienne Garin, nuclear medicine physician, Cancer Centre Eugène Marquis, Rennes, France, received the gold medal at the Global Embolization Oncology Symposium Technologies (GEST) 2019 meeting for his work on the Investigator Initiated Study (IIS) Dosisphere. This study compared the efficacy of TheraSphere in 56 patients with at least one lesion > 7cm, using a personalized approach with Simplicit90Y dosimetry software versus standard dosimetry.  Higher response rates of 71 percent were seen in the personalized prospective dosimetry arm versus 36 percent with standard dosimetry. "The future for radioembolization is personalised dosimetry," said Garin, principal investigator of the study.

"The working group reached a consensus recommendation on simple, reproducible and evidence-based practice for personalized treatment of HCC patients with TheraSphere. This publication significantly advances our knowledge of dosimetry and will help to improve clinical outcomes" said Prof. Riad Salem, chief of interventional radiology, Northwestern Memorial Hospital, Chicago. The paper1 combines conclusions from the peer-reviewed literature together with expert opinion and includes curative and palliative therapy, categorized into four clinical scenarios: radiation segmentectomy, lobectomy, multifocal unilobar or bilobar disease, and HCC with macrovascular invasion. For each scenario, recommendations are provided on patient selection, treatment planning and dosimetry, treatment delivery and outcome assessment, and degree of recommendation and the strength of consensus.

Watch the VIDEO: Y90 Embolization of Liver Cancer at Henry Ford Hospital

For more information: www.therasphere.com

References

1.  Salem R, Padia S, Lam M et al. Eur J Nucl Med Mol Imaging. 2019 May 16. doi: 10.1007/s00259-019-04340-5. [Epub ahead of print]

2.  Garin E, Tselikas L, Guiu B et al. A multicentric randomised study demonstrating the impact of MAA based dosimetry on tumour response with Y90 loaded glass microsphere SIRT for HCC:  interim analysis of IIS Dosisphere [Poster presentation ECIO 2019 & oral presentation GEST 2019]

Related Content

Image by Dr. Manuel González Reyes from Pixabay

Image by Dr. Manuel González Reyes from Pixabay 

News | SPECT Imaging | November 08, 2019
November 8, 2019 — Using ground-breaking technology, researchers at the...
Philips Medical System is recalling its older Forte Gamma Camera SPECT imaging systems due to the possibility of the detectors falling off of the unit onto the patient. The two gamma cameras can bee seen in this photo on either side of the patient bed. These can be rotated above the patient.

Philips Medical System is recalling its older Forte Gamma Camera SPECT imaging systems due to the possibility of the detectors falling off of the unit onto the patient. The two gamma cameras can be seen in this photo on either side of the patient bed. These can be rotated above the patient.

Feature | Nuclear Imaging | November 05, 2019 | Dave Fornell, Editor
November 5, 2019 — Philips Medical System is recalling the Forte Gamma Camera System due to the potential for the 660
Harel Gadot

Harel Gadot, Founder, Executive Chairman and President at XACT Robotics says their system’s small footprint and high mobility design will enable care providers to treat a broad range of patient care needs.

News | Interventional Radiology | November 01, 2019
November 1, 2019 — XACT Robotics Ltd. announced that its firs
The Alphenix Aero Package from Canon Medical Systems USA, Inc. enables OBLs and ASCs to attain premium technology at a flexible price point by tailoring Canon Medical’s Alphenix systems to fit their facilities’ needs.

The Alphenix Aero Package from Canon Medical Systems USA, Inc. enables OBLs and ASCs to attain premium technology at a flexible price point by tailoring Canon Medical’s Alphenix systems to fit their facilities’ needs.

Technology | Interventional Radiology | October 28, 2019
October 28, 2019 — Office based labs (OBLs) and ambulatory surgery centers (ASCs) require a fresh perspective from im
 Phoenix’s fusion neutron generation technology.
News | Radiopharmaceuticals and Tracers | October 28, 2019
October 28, 2019 — Phoenix LLC and Shine Medical Technologies LLC, nuclear technology companies focused on near-term
Exact Imaging Receives FDA 510(k) Clearance for Sterile Transperineal Needle Guide
Technology | Ultrasound Imaging | October 24, 2019
Exact Imaging received U.S. Food and Drug Administration (FDA) 510(k) clearance for its Sterile Transperineal Needle...
GE Healthcare and Theragnostics Partnering on PSMA PET/CT Imaging Agent
News | Prostate Cancer | October 16, 2019
GE Healthcare and Theragnostics have entered into a global commercial partnership for a new prostate-specific membrane...
Canon Medical Launches Alphenix Encore Plus Program
News | Angiography | October 09, 2019
In the complex and fast-paced world of healthcare, customers face the challenge of staying up-to-date with the most...
The Artis icono biplane angiography system is designed for use in neurointerventions and interventional radiology

The Artis icono biplane angiography system is designed for use in neurointerventions and interventional radiology. Image courtesy of Siemens Healthineers.

Technology | Angiography | September 17, 2019
The U.S. Food and Drug Administration (FDA) has cleared the Artis icono, a high-precision family of angiography systems...