The British Heart Foundation (BHF) announced the winners of its annual ‘Reflections of Research’ image competition, reflecting the charity’s research into heart and circulatory disease.
Positron emission tomography (PET) with three different radiotracers can now measure amyloid plaques, tau tangles and metabolic activity in the brains of living Alzheimer’s patients.
Three medical professional societies this week jointly released a new reporting system to standardize reporting of patients undergoing coronary computed tomography angiography (coronary CTA).
Final United States Preventive Services Task Force (USPSTF) colorectal cancer screening recommendations assigned an “A” grade to colorectal cancer (CRC) screening in those ages 50-75 years and provided a list of recognized screening exams.
An emerging molecular imaging technique may provide a way to break the perpetual cycle of abuse of alcoholism. It could signal patients’ heightened risk and lead to targeted drug treatments that reduce the compulsion to drink, said researchers presenting at the 2016 Annual Meeting of the Society of...
This image shows blood flow within the main pumping chambers – the ventricles – on both sides of the heart and the vessels leaving the heart. The blue flow is blood that needs oxygen and is travelling to the lungs. The red flow is blood that has been through the lungs and received oxygen. Victoria Stoll of the University of Oxford is using this type of imaging to look at the blood flow within the hearts of people with heart failure, whose hearts are not pumping effectively.
NET circulating transcript and chromogranin A (CgA) levels in responders and non-responders. a) Transcripts were significantly reduced at 6-month follow-up compared to pre-treatment values. Non-responders (NR) exhibited significantly elevated levels at 6 months (FUP_6m). This was also significantly higher than in responders (R). b) A significant alteration was noted only for CgA in non-responders (NR) at 6 months. c) Pre-PRRT: NET transcript scores were elevated in 94 percent and CgA in 57 percent. d) Responders: NET transcripts decreased in 88 percent of responders (no change in 12 percent). CgA was unchanged in 47 percent, decreased in 21 percent and was elevated in 32 percent. e) Non-Responders: NET transcripts increased in 90 percent (no change in 10 percent). CgA was unchanged in 33 percent, decreased in 40 percent and was elevated in 27 percent. For NET transcripts, no falsely decreased or increased values occurred in responders or non-responders, respectively. Credit: LuGenIum Consortium for Independent Research & Wren Laboratories
A. Increased F-18 TZ3504 uptake was observed in the inflamed lumbar spinal cord of EAE-treated animals in the rat model of MS compared to sham control rats. Representative sagittal, coronal and transverse views of the thoracic and lumbar spine are shown. B. The time activity curve of F-18 TZ3504 uptake in the lumbar spinal cord was significantly higher for the first 30 minutes in EAE-treated rats. C. F-18 TZ3504 was able to cross the blood brain barrier and showed homogeneous distribution in the brain of a healthy nonhuman primate. Image Credit: Mallinckrodt Institute of Radiology at the Washington University School of Medicine, St. Louis, Mo.
Comparison of Ga-68-DOTATOC PET/CT with Y-90 DOTATOC PET/CT. Although the positron associated with Y-90 is rarely emitted, there is still sufficient signal to acquire a quantitative PET/CT image of Y-90 DOTATOC after a therapeutic administration. The white arrows indicate kidneys and the yellow arrows tumor. Credit: University of Iowa
Adding this variable angle slant hole collimator to an existing breast molecular imaging system allows the system to get six times better contrast of cancer lesions in the breast, providing the same or better image quality while also potentially reducing the radiation dose to the patient by half. Technologies developed at DOE’s Jefferson Lab for the variable angle slant hole collimator are included in two filings to the U.S. Patent and Trademark Office. Image courtesy of DOE’s Jefferson Lab.
Illustration of three-step DOTA-PRIT based on targeting with an IgG-scFv bispecific antibody (e.g., huA33-C825 for detection and treatment of colorectal cancer) with dual specificity for a tumor-associated antigen (e.g., GPA33) and M-DOTA haptens (e.g., Lu-177 DOTA). Image courtesy of Memorial Sloan Kettering Cancer Center.
Topographical correspondence of tau- but not amyloid-pathology with neuronal dysfunction in Alzheimer’s disease
Right lateral surface of projected z-score images, reflecting deviation from healthy controls
Yellow/red: higher uptake, blue: lower uptake as compared to controls
Image courtesy of G. Bischof, J. Hammes, T. van Eimeren, A. Drzezga, Multimodal Neuroimaging Group, Dept. of Nuclear Medicine, University of Cologne; B. Neumaier, Institute of Radiochemistry and Experimental Molecular Imaging University of Cologne; J. Dronse, O. Onur, J. Kukolja, G. Fink, F. Jessen, Center for Memory Disorders, Depts. of Neurology & Psychiatry, University of Cologne; and K. Fliessbach, Dept. of Neurology, University of Bonn.