62-year-old with serum PSA level of 4.11 ng/mL. Prostate MRI shows lesion in left mid anterior transition zone

62-year-old with serum PSA level of 4.11 ng/mL. Prostate MRI shows lesion in left mid anterior transition zone. Lesion (arrow) shows hypointensity on T2-weighted image (A), hyperintensity on high b-value DWI (B), hypointensity on ADC map (C), and focal early enhancement on dynamic contrast-enhanced image (D). Lesion assessed as category 4 using PI-RADS version 2.1 MRI-targeted biopsy of lesion revealed prostate adenocarcinoma with International Society of Urogenital Pathology (ISUP) grade group 2. At subsequent radical prostatectomy performed 6 months after biopsy, ISUP grade group upgraded to 3. 


September 22, 2023 — According to an accepted manuscript published in the American Journal of Roentgenology (AJR), upgrade and downgrade rates from targeted biopsy to radical prostatectomy were not significantly different between patients whose MRI examinations were clinically interpreted using PI-RADS Version v2.0 or v2.1. 

“Implementation of the most recent PI-RADS update did not improve the incongruence in prostate cancer grade assessment between targeted biopsy and surgery,” wrote corresponding author Baris Turkbey, MD, from the Molecular Imaging Branch of the National Cancer Institute at National Institutes of Health in Bethesda, MD. 

Dr. Turkbey and colleagues’ AJR study entailed a retrospective post-hoc analysis of patients who underwent 3-T prostate MRI at a single institution from May 2015 to March 2023 during prospective clinical trials. From trial participants, the authors identified those who underwent MRI followed by MRI/ultrasound-fusion guided targeted biopsy and radical prostatectomy within a 1-year interval. A single genitourinary radiologist performed clinical interpretations of the MRI examinations using PI-RADS v2.0 from May 2015 to March 2019, and using PI-RADS v2.1 from April 2019 to March 2023. 

Ultimately, patients who underwent MRI interpreted by PI-RADS v2.0 and PI-RADS v2.1 showed no significant differences in respective rates of upgrade (29% vs. 22%, p = .15), downgrade (19% vs. 21%, p = .76), clinically significant upgrade (14% vs. 10%, p = .27), or clinically significant downgrade (1% vs. 1%, p>.99) from targeted biopsy to radical prostatectomy grade group. 

For more information: www.arrs.org 

 

Related prostate MRI content: 

New AI Tool for Prostate MRI Analysis to Support PI-RADS Scoring 

MRI-guided Radiotherapy Appears to Lead to Fewer Side Effects from Treatment for Prostate Cancer 

Mount Sinai Health System Launches First-Ever Mobile Prostate Cancer Screening Unit in New York City 

Genetics Predicts Toxic Side Effects to Prostate Cancer Radiotherapy 

3-D Imaging Method May Help Doctors Better Determine Prostate Cancer Aggressiveness 

Black Patients 24% Less Likely than White Patients to Have a Prostate MRI After Receiving an Elevated PSA Score


Related Content

News | ASTRO

May 17, 2024 — Registration opens today for the American Society for Radiation Oncology's (ASTRO) 66th Annual Meeting ...

Time May 17, 2024
arrow
News | Cardiac Imaging

May 17, 2024 — The Cum Laude Award-Winning Online Poster presented during the 124th ARRS Annual Meeting found that the ...

Time May 17, 2024
arrow
News | Radiation Therapy

May 16, 2024 — Today marks a significant milestone in cancer care with the introduction of bipartisan federal ...

Time May 16, 2024
arrow
News | Pediatric Imaging

May 15, 2024 — Transfer learning (TL) models trained on heterogeneous public datasets and fine-tuned using institutional ...

Time May 15, 2024
arrow
News | FDA

May 14, 2024 — Indica Labs, the leading provider of digital pathology solutions, announced today that it received FDA ...

Time May 14, 2024
arrow
News | Radiology Business

May 14, 2024 — University Hospitals (UH) and Siemens Healthineers announce a 10-year strategic alliance that builds on ...

Time May 14, 2024
arrow
News | Artificial Intelligence

May 14, 2024 — Elekta announced the launch of its latest linear accelerator (linac), Evo*, a CT-Linac with new high ...

Time May 14, 2024
arrow
News | Prostate Cancer

May 13, 2024 — Avenda Health, an AI healthcare company creating the future of personalized prostate cancer care, unveils ...

Time May 13, 2024
arrow
News | Radiology Imaging

May 13, 2024 — National Basketball Association (NBA), the National Basketball Players Association (NBPA), and the Next ...

Time May 13, 2024
arrow
News | Breast Imaging

May 10, 2024 — According to the Summa Cum Laude Award-Winning Online Poster presented during the 124th ARRS Annual ...

Time May 10, 2024
arrow
Subscribe Now