News | Advanced Visualization | January 20, 2016

Virtual Bone Biopsy Identifies Source of Bone Fracture Risk in Diabetics

High-resolution peripheral quantitative CT reveals patients with type 2 diabetes have structural defects that could be treated to prevent future fractures

University of Southampton, HR-pQCT, type 2 diabetes, bone fracture risk

Three dimensional structure of a human tibia obtained by high-resolution-peripheral quantitative computer tomography (HR-pQCT) scanning and showing compact bone (periphery) and trabecular bone (center). (Credit NASA and Bone Imaging Laboratory, University of Calgary, Canada)

January 20, 2016 — A University of Southampton study using high-resolution imaging to create a “virtual bone biopsy” has shed new light on why people with type 2 diabetes are at risk of bone fractures.

Researchers from the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, used high-resolution peripheral quantitative computed tomography (HRpQCT) to assess bone structure and strength at a microstructural level in living patients.

The images showed that individuals with type 2 diabetes have structural defects within their bones, which could weaken them and go some way to explaining the greater rates of fracture found in older men and women with the disease.

Lead researcher Mark Edwards, Ph.D., clinical lecturer at the University of Southampton, commented: “This is a very interesting discovery using a very novel technique. We’ve known for some time that people with type 2 diabetes are at risk of fracture but have not been able to fully explain why.

“This new imaging technique has been able to identify that the cortical component of bone – the outer rim of the bone – tends to exhibit greater porosity in those with type 2 diabetes compared to those without. We can now see where there is a specific deficit within the bone, which may help clinicians to develop appropriate therapies to prevent future fractures.”

The study, which is published in Calcified Tissue International, scanned a group of 177 men and 155 women, who were part of the Hertfordshire Cohort Study. Their average age was around 76 years at the time of the study.

Prof. Cyrus Cooper, director of the MRC Lifecourse Epidemiology Unit, University of Southampton, commented: “This study highlights an important link between diabetes and osteoporosis, and identifies a selective deficit in skeletal development, which leads to excess fracture risk in this increasingly frequent disorder. It also demonstrates that environmental influences during critical periods of early development might lead to several common non-communicable disorders in western populations.”

For more information: www.mrc.soton.ac.uk

Related Content

Guerbet Signs Agreement With Icometrix for Exclusive Distribution of Icobrain
News | Neuro Imaging | October 16, 2019
Guerbet announced it has signed an exclusive agreement with Icometrix for the distribution in France, Italy and Brazil...
Sponsored Content | Whitepapers | Clinical Trials | October 09, 2019
A 2019 N G PX REPORT
RSNA Announces Intracranial Hemorrhage AI Challenge
News | Artificial Intelligence | October 08, 2019
The Radiological Society of North America (RSNA) recently launched its third annual artificial intelligence (AI)...
AI Accurately Detects Key Chest X-Ray Pneumonia Findings Within 10 Seconds
News | Artificial Intelligence | September 30, 2019
Researchers from Intermountain Healthcare and Stanford University say 10 seconds is about how quickly a new system they...
University of Arizona to Develop New CT-Based Breast Cancer Diagnostic Imaging Method
News | Breast Imaging | September 27, 2019
Researchers at the University of Arizona Health Sciences are seeking a new and more accurate way to diagnose breast...
AI Accurately Predicts Radiotherapy Side Effects for Head and Neck Cancer Patients
News | Artificial Intelligence | September 26, 2019
For the first time, a sophisticated computer model has been shown to accurately predict two of the most challenging...
Brainlab Introduces Loop-X Mobile Intraoperative Imaging Robot
News | Mobile C-Arms | September 26, 2019
Digital medical technology company Brainlab unveiled Loop-X, which it calls the first mobile intraoperative imaging...
FDA Clears Modules of AI-Rad Companion Chest CT From Siemens Healthineers
Technology | Computed Tomography (CT) | September 26, 2019
The U.S. Food and Drug Administration (FDA) has cleared three modules of AI-Rad Companion Chest CT, an intelligent...
Machine Learning Could Offer Faster, More Precise Cardiac MRI Scan Results
News | Magnetic Resonance Imaging (MRI) | September 25, 2019
Cardiac magnetic resonance imaging (MRI) analysis can be performed significantly faster with similar precision to...
Virtual Reality 3-D Models Help Yield Better Surgical Outcomes

Joseph Shirk, M.D., of UCLA with the virtual reality headset. Image courtesy of UCLA Jonsson Comprehensive Cancer Center

News | Virtual and Augmented Reality | September 25, 2019
A UCLA-led study has found that using three-dimensional virtual reality (VR) models to prepare for kidney tumor...