News | PET-CT | November 15, 2019

PET/CT Plays Role in Lung Adenocarcinoma Management

62-year-old woman with pure ground-glass nodules (GGN). PET/CT fusion image shows pure GGN with tumor maximum standardized uptake value of 2.8 (circle).

62-year-old woman with pure ground-glass nodules (GGN). PET/CT fusion image shows pure GGN with tumor maximum standardized uptake value of 2.8 (circle).

November 15, 2019 — According to an article published ahead-of-print in the February 2020 issue of the American Journal of Roentgenology (AJR), fluorodeoxyglucose PET (FDG PET) can be used to predict the histopathologic subtypes and growth patterns of early lung adenocarcinoma.

“FDG PET, combined with high-resolution CT (HRCT), has value for predicting invasive histopathologic subtypes, but there was no significance for predicting invasive growth patterns,” clarified lead author Xiaoliang Shao from the department of nuclear medicine at Soochow University in Changzhou, China.

Shao and colleagues’ retrospective analysis was conducted on the PET/CT data on ground-glass nodules (GGNs) resected from patients with stage IA lung adenocarcinoma, evaluating the efficacy of PET maximum standardized uptake value (SUVmax) combined with HRCT signs in prediction of histopathologic subtype and growth pattern of lung adenocarcinoma.

Although SUVmax measured significantly higher in GGNs with invasive HRCT signs, the diameter of GGN, as well as the attenuation value differential between ground-glass components and adjacent lung tissues, were independent predictors of FDG uptake by GGNs.

Additionally, SUVmax was higher in invasive adenocarcinoma than in adenocarcinoma in situ (AIS)–minimally invasive adenocarcinoma (MIA), with SUVmax 2.0 the optimal cutoff value for differentiation.

Acinar-papillary adenocarcinoma had a higher SUVmax than lepidic adenocarcinoma, with SUVmax 1.4 the optimal cutoff value for differentiation.

Parameter measurements of pure ground-glass nodules (GGNs) and part-solid GGNs on PET/CT fusion and high-resolution CT (HRCT) images.

62-year-old woman with pure GGN. PET/CT fusion image shows pure GGN with tumor maximum standardized uptake value (SUVmax) of 2.8 (circle).

“In stage IA lung adenocarcinoma characterized by GGNs, the SUVmax of GGNs with invasive CT features was high,” Shao wrote, adding that HRCT can be used in diagnosing the subtypes of lung adenocarcinoma. “However, it cannot be used to differentiate different growth patterns of lung adenocarcinomas.”

As Shao concluded: “The efficacy of FDG PET SUVmax in differentiating lung adenocarcinoma subtypes is similar to that of HRCT signs, however, the diagnostic efficiency of FDG PET combined with HRCT is significantly higher than that of each imaging technique alone.”

For more information: www.arrs.org/

Related Content

#COVID19 #Coronavirus #2019nCoV #Wuhanvirus #SARScov2 New studies use SIRD model to forecast COVID-19 spread; examine patient CT scans to correlate clinical features with mortality

Fig 1. A sample scoring on CT images of a 63-year-old woman from mortality group demonstrated a total score of 63. It was calculated as: for upper zone (A), 3 (consolidation) × 3 (50–75% distribution) × 2 (both right and left lungs) + 2 (ground glass opacity) ×1 (< 25% distribution) × 2 (both right and left lungs); for middle zone (B), 3 (consolidation) × 2 (25–50% distribution) × 2 (both right and left lungs) + 2 (ground glass opacity) × 2 (25–50% distribution) × 2 (both right and left lungs); for lower zone (C), 3 (consolidation) × (2 (25–50% distribution of the right lung) + 3 (50–75% distribution of the left lung)) + 2 (ground glass opacity) × (2 (25–50% distribution of the right lung) + 1 (< 25% distribution of the left lung)) Yuan et al, 2020 (CC BY 4.0)

News | Coronavirus (COVID-19) | April 01, 2020
April 1, 2020 — A new study, ...
#COVID19 #Coronavirus #2019nCoV #Wuhanvirus #SARScov2 Company emphasizes faster, more advanced CTs, making imaging easier for COVID-19 patients
News | Computed Tomography (CT) | April 01, 2020
April 1, 2020 — United Imaging, a global leader in advanc
#COVID19 #Coronavirus #2019nCoV #Wuhanvirus #SARScov2 A brief article from Henry Ford Health System in Detroit, published today in Radiology, reports on the first presumptive case of COVID-19–associated acute necrotizing hemorrhagic encephalopathy.

A, Image from noncontrast head CT demonstrates symmetric hypoattenuation within the bilateral medial thalami (arrows). B, Axial CT venogram demonstrates patency of the cerebral venous vasculature, including the internal cerebral veins (arrows). C, Coronal reformat of aCT angiogram demonstrates normal appearance of the basilar artery and proximal posterior cerebral arteries. Image courtesy of the Radiological Society of North America (RSNA)

News | Coronavirus (COVID-19) | March 31, 2020
March 31, 2020 — A brief article fr
#COVID19 #Coronavirus #2019nCoV #Wuhanvirus #SARScov2 The Chinese start-up company Infervision launches its AI-based solution InferRead CT Lung Covid-19 also in Europe
News | Artificial Intelligence | March 31, 2020
March 31, 2020 — Lung infections generated by the coronavirus can be detected in...
#COVID19 #Coronavirus #2019nCoV #Wuhanvirus #SARScov2 Doctor in our hospital is using this intelligent system for accurate diagnosis

Doctor in our hospital is using this intelligent system for accurate diagnosis. (Photo: Business Wire)

News | Artificial Intelligence | March 31, 2020
March 31, 2020 — The Intelligent Evalua...
#COVID19 #Coronavirus #2019nCoV #Wuhanvirus #SARScov2
News | Coronavirus (COVID-19) | March 31, 2020
March 31, 2020 — In a...
AI tool predicts which patients newly infected with COVID-19 will eventually develop severe respiratory disease #COVID19 #Coronavirus #2019nCoV #Wuhanvirus #SARScov2
News | Artificial Intelligence | March 31, 2020
March 31, 2020 — An artificial intelligence tool accurately predicted which patients newly infected with the...
RSNA's open data repository will compile images and correlative data to create a comprehensive source for COVID-19 research and education efforts #COVID19 #Coronavirus #2019nCoV #Wuhanvirus #SARScov2
News | Coronavirus (COVID-19) | March 30, 2020
March 30, 2020 — The medical imaging community around the world is uniting to help address the...
Phase III response to the COVID-19 public health emergency (PHE) CARES Act signed into law #CARESAct #COVID19 #Coronavirus #2019nCoV #Wuhanvirus #SARScov2
Feature | Coronavirus (COVID-19) | March 28, 2020 | By Melinda Taschetta-Millane
On March 27, the House of Representatives approved a historic $2