News | Artificial Intelligence | May 08, 2019

Novel Artificial Intelligence Method Predicts Future Risk of Breast Cancer

AI model combines traditional risk factors with breast density and other information from the mammogram to enhance risk prediction

Novel Artificial Intelligence Method Predicts Future Risk of Breast Cancer

May 8, 2019 — Researchers from two major institutions have developed a new tool with advanced artificial intelligence (AI) methods to predict a woman's future risk of breast cancer, according to a new study published in the journal Radiology.1

Identifying women at risk for breast cancer is a critical component of effective early disease detection. However, available models that use factors such as family history and genetics fall far short in predicting an individual woman's likelihood of being diagnosed with the disease.

Breast density — the amount of dense tissue compared to the amount of fatty tissue in the breast on a mammogram — is an independent risk factor for breast cancer that has been added to some models to improve risk assessment. It is based on subjective assessment that can vary across radiologists, so deep learning, a subset of AI in which computers learn by example, has been studied as a way to standardize and automate these measurements.

"There's much more information in a mammogram than just the four categories of breast density," said study lead author Adam Yala, Ph.D. candidate at the Massachusetts Institute of Technology (MIT) in Cambridge, Mass. "By using the deep learning model, we learn subtle cues that are indicative of future cancer."

Yala, in collaboration with Regina Barzilay, Ph.D., an AI expert and professor at MIT, and Constance Lehman, M.D., Ph.D., chief of breast imaging at Massachusetts General Hospital (MGH) in Boston and professor of radiology at Harvard Medical School, recently compared three different risk assessment approaches. The first model relied on traditional risk factors, the second on deep learning that used the mammogram alone, and the third on a hybrid approach that incorporated both the mammogram and traditional risk factors into the deep learning model.

The researchers used almost 90,000 full-resolution screening mammograms from about 40,000 women to train, validate and test the deep learning model. They were able to obtain cancer outcomes through linkage to a regional tumor registry.

The deep learning models yielded substantially improved risk discrimination over the Tyrer-Cuzick model, a current clinical standard that uses breast density in factoring risk. When comparing the hybrid deep learning model against breast density, the researchers found that patients with non-dense breasts and model-assessed high risk had 3.9 times the cancer incidence of patients with dense breasts and model-assessed low risk. The advantages held across different subgroups of women.

"Unlike traditional models, our deep learning model performs equally well across diverse races, ages and family histories," Barzilay said. "Until now, African-American women were at a distinct disadvantage in having accurate risk assessment of future breast cancer. Our AI model has changed that."

"There's a very large amount of information in a full-resolution mammogram that breast cancer risk models have not been able to use until recently," Yala added. "Using deep learning, we can learn to leverage that information directly from the data and create models that are significantly more accurate across diverse populations."

AI-assisted breast density measurements are already in use for screening mammograms performed at MGH. The researchers are tracking its performance in the clinic while working on refining the ways to communicate risk information to women and their primary care doctors.

"A missing element to support more effective, more personalized screening programs has been risk assessment tools that are easy to implement and that work across the full diversity of women whom we serve," Lehman said. "We are thrilled with our results and eager to work closely with our healthcare systems, our providers and, most importantly, our patients to incorporate this discovery into improved outcomes for all women."

For more information: www.pubs.rsna.org/journal/radiology

 

Reference

1. Yala A., Lehman C., Schuster T., et al. A Deep Learning Mammography-based Model for Improved Breast Cancer Risk Prediction. Radiology, May 7, 2019. https://doi.org/10.1148/radiol.2019182716

Related Content

 Laurel Bridge Machine Learning workflow
News | Artificial Intelligence | November 08, 2019
November 8, 2019 — Laurel Bridge Software announces the new Laurel Bridge
Bladder Abdomen Pelvis image with DLCExpert
News | Artificial Intelligence | November 07, 2019
November 7, 2019 — Mirada Medical, a global leader in...
Kubtec has made the Marcum Tech Top 40 (TT40) list of fastest growing technology companies in Connecticut
News | Radiology Business | November 06, 2019
November 6, 2019 — The Connecticut Technology Council (CTC) and...
Using artificial intelligence to predice risk of thyroid cancer on ultrasound.

Using artificial intelligence to predice risk of thyroid cancer on ultrasound.

News | Artificial Intelligence | November 06, 2019
November 6, 2019 — Thyroid nodules are small lumps that form within the thyroid gland and are quite common in the gen
Sectra
News | Artificial Intelligence | November 01, 2019
November 1, 2019 — At RSNA 2019, Sectra will showc
 Emergent Connect pneumothorax image

The partnership will bring the power of AI to Emergent Connect's growing customer base, leaving zero-footprint on the client side and eliminating the need for on premise installation and local workstation configurations. 

News | Artificial Intelligence | October 31, 2019
October 31, 2019 — Zebra Medical Vision, a deep learning medical imaging ana
The U.S. market is unique in that it formed over 55 percent of the global market in 2018

The U.S. market is unique in that it formed over 55 percent of the global market in 2018.

Feature | Mammography | October 30, 2019 | By Imogen Fitt
When breast imaging comes to mind, mammography is the undisputed current modality of choice.
2-D mole marker

2-D mole marker used in 3-D, Slice 1 of 59

Sponsored Content | Case Study | Breast Imaging | October 30, 2019
When it comes to the use of mammography skin markers in dig...
Attendees of ASTRO 2019 walked the halls of McCormick Place in Chicago, Ill.

Attendees of ASTRO 2019 walked the halls of McCormick Place in Chicago, Ill.

Feature | ASTRO | October 30, 2019 | By Greg Freiherr
At the American Society for Radiation Oncology’s (ASTRO) 2019 a