News | November 15, 2010

New Imaging Technology Predicts Fracture Risk

3-D thickness map

November 15, 2010 — A new method for identifying which bones have a high risk of fracture and for monitoring the effectiveness of new bone-strengthening drugs and techniques has been developed by scientists at the University of Cambridge in Cambridge, UK. The method, developed by Dr. Graham Treece of the Department of Engineering and Dr. Ken Poole of the Department of Medicine, uses computed tomography (CT) imaging to accurately measure the thickness of the cortical bone, the hard outer layer of compact bone which surrounds the spongy trabecular bone. The thickness of cortical bone is a key indicator of the risk of fracture, including in conditions such as osteoporosis.

When CT rays pass through thin, radiodense layers such as the cortical bone, the resulting images are slightly blurred. Understanding the mathematics of how this blurring occurs has allowed the researchers to develop an image analysis process that provides an accurate measurement of the cortical thickness at a particular point on the bone. Importantly, this method remains accurate in the clinically relevant sub-millimeter range and can be achieved using routine CT scans.

The cortical thickness measurement can be obtained for thousands of points on the surface of a bone, thus providing a thickness map. This, in turn, allows clinicians to identify bones that exhibit thinning of the cortical bone at the key points that are known to be associated with an increased risk of fracture. Successive mapping over time allows maps to be produced depicting changes in the cortical bone over time in all areas of the skeleton, so that the progress of osteoporosis treatments can be monitored.

The current technologies do not provide for this level of functionality. Dual-energy X-ray absorptiometry (DXA) provides a measure of mineral levels across the whole bone, not a 3-D map, whereas multi-detector computed tomography (MDCT) does not achieve the sub-millimeter resolution provided by this novel approach.

“Osteoporosis is a condition which will become more and more common as the population ages,” said Dr. Andrew Walsh of Cambridge Enterprise, the University’s commercialization group. “This exciting innovation has the potential to improve the treatment of patients suffering from osteoporosis, as well as to support the development of new drugs. We are currently seeking commercial partners to help us achieve this benefit by bringing this technology to market.”

This work will be demonstrated at RSNA 2010.

For further information: www.enterprise.cam.ac.uk

Related Content

CT_Pediatric_Scan_Philips_Vereos_CT_RSNA 2016

Image courtesy of Philips Healthcare

News | Pediatric Imaging | December 10, 2019
December 10, 2019 — More than half of people who received...
Damage from concussion alters the way information is transmitted between the two halves of the brain, according to a new study presented today at the annual meeting of the Radiological Society of North America (RSNA).

Image courtesy of RSNA

News | Clinical Trials | December 10, 2019
December 10, 2019 — Damage from...
After receiving acupuncture treatment three days a week during the course of radiation treatment, head and neck cancer patients experienced less dry mouth, according to study results from researchers at The University of Texas MD Anderson Cancer Center

Image by Rudolf Langer from Pixabay 

News | Clinical Trials | December 06, 2019
December 6, 2019 — After receiving acupuncture treatment three days a week during the course of...
Timothy Whelan is a professor of oncology at McMaster University and a radiation oncologist at the Juravinski Cancer Centre of Hamilton Health Sciences. He holds a Canada Research Chair in Breast Cancer Research. Photo courtesy McMaster University

Timothy Whelan is a professor of oncology at McMaster University and a radiation oncologist at the Juravinski Cancer Centre of Hamilton Health Sciences. He holds a Canada Research Chair in Breast Cancer Research. Photo courtesy McMaster University. Photo courtesy of McMaster University

News | Breast Imaging | December 06, 2019
December 6, 2019 — A shorter course of higher-dose radiation treatment to part of the breast is showing promise in wo
MRI Exablate neuro helmet from INSIGHTEC

MRI Exablate neuro helmet from INSIGHTEC. Image courtesy of Ali Rezai, M.D., and RSNA.

News | Clinical Trials | December 03, 2019
December 3, 2019 — Focused ultrasound is a safe and effective way to target and open areas of the blood-brain barrier
Image by Kira Hoffmann from Pixabay  #RSNA19

Image by Kira Hoffmann from Pixabay 

News | Clinical Trials | November 30, 2019
November 30, 2019 — Researchers are trying to identify injury patterns and predict future outcomes for victims of gun
This bar graph shows breast cancer presentation by screening interval #RSNA19

This bar graph shows breast cancer presentation by screening interval. Image courtesy of study author and RSNA

News | Breast Imaging | November 28, 2019
November 28, 2019 — Cancers found in patients undergoing annual...
Prof. Dr. Samer Ezziddin from Saarland University/Saarland University Hospital.

Prof. Dr. Samer Ezziddin from Saarland University/Saarland University Hospital. Photo courtesy of Thorsten Mohr/Saarland University

News | Prostate Cancer | November 28, 2019
November 28, 2019 — Reports of new cancer treatments